@dregenus @DasErste Es verhält sich in den Symptomen ähnlich zu einem Atemwegsinfekt, verursacht aber im Körper ganz andere Schäden als ein "Erkältungsvirus". Könnte man wissen... wenn man will. https://t.co/kPS0PyNzA6 https://t.co/RRWwlwpcnz https://t.
@GrGuenter @ejustin46 But differences as well, which is logical, eg between oc43 & sars-cov2 (lab study) https://t.co/DGuumThMMd https://t.co/CMEqkIbIBE
コロナ血小板症と内皮症 https://t.co/OUBXse26cZ 血小板→内皮症⬆️ https://t.co/U6kYEvpq5Z スラミンはHIV、エボラ、ジカ熱、SARS ヘパラン硫酸(HS)等の細胞表面糖を要す🦠阻止 https://t.co/7sylPxkEfR スラミンはコロナ3CL protease阻害 https://t.co/HuwTks3mM5 3CL pro https://t.co/GafpazkgyO https://t.co/mRC0YdBZae
Ticagrelor https://t.co/sVOnVbcEF9
https://t.co/9TJE87QUqK "The clinical effect of a P2Y12 inhibitor strategy is being investigated in ACTIV4a (NCT04505774)." https://t.co/jboGvzAdZb
https://t.co/9TJE87QUqK "P2Y12 inhibition will mitigate platelet activation, reduce platelet-released MRP8/14, and ultimately suppress platelet activity and EC activation and improve clinical outcomes linked to #COVID19 thromboinflammation."
https://t.co/9TJE87QUqK "While aspirin had no significant effect, ticagrelor led to a significant reduction in both expression of platelet S100A8 and S100A9 mRNA (P < 0.0001)"
https://t.co/9TJE87QUqK "silencing CD36 significantly suppressed #COVID19 platelet-mediated EC IL6 and IL8 cytokine production. These data suggest that platelet-released MRP8/14 mediate the proinflammatory effect of #COVID19 EC inflammation via CD36."
https://t.co/9TJE87QUqK "MRP8/14 is a ligand for innate receptors, including Toll-like receptor 4 (TLR4), CD36, and receptor for advanced glycation end products (RAGE)."
https://t.co/9TJE87QUqK "A positive correlation existed between platelet-released MRP8/14 and microvascular EC IL8 and IL6 production (P = 0.001 and P = 0.007, respectively), suggesting that platelet-derived MRP8/14 is a driver of EC activation."
https://t.co/9TJE87QUqK "MRP8/14 activates microvascular ECs and weakens EC cell-cell contacts, resulting in increased permeability of the endothelium."
https://t.co/9TJE87QUqK "#COVID19 platelets released significantly increased levels of MRP8/14" "platelet-derived MRP-14 promotes MPA formation and a proinflammatory monocyte phenotype"
https://t.co/9TJE87QUqK "MRP8 and MRP14 heterodimerize to produce the inflammatory product MRP8/14 (calprotectin), an inflammatory protein present within platelet granules and released by activated platelets"
Platelets amplify endotheliopathy in #COVID19 https://t.co/9TJE87QUqK "S100A8 and S100A9 genes code for MRP8 and MRP14 and were among the top 4 identified transcripts enriched in platelets from #COVID19 patients to have a released product." https://t.co/
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
@EllaSloman • Platelets amplify endotheliopathy in COVID-19 • Sept 8, 2021 • https://t.co/uG40w3kn2U
RT @PlateletDoc: Pleased to share 18 months of work demonstrating how #platelets play a major pathogenic role in #Covid_19 and amplify endo…
RT @renesugar: Platelets amplify endotheliopathy in #COVID19 #LongCovid https://t.co/jp7ee4AGmd "factors known to be released from platel…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
Platelets amplify endotheliopathy in #COVID19 #LongCovid https://t.co/jp7ee4AGmd "factors known to be released from platelets that are increased in #COVID19 patients (IL6, P-selectin, and sCD40L)"
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @CastlTrAstonDrs: #IDtwitter #Cardiotwitter #P2Y12 inhibitors (Ticagrelor) may be useful in Platelet-directed Tx & its effect on platele…
RT @CastlTrAstonDrs: #IDtwitter #Cardiotwitter #P2Y12 inhibitors (Ticagrelor) may be useful in Platelet-directed Tx & its effect on platele…
#IDtwitter #Cardiotwitter #P2Y12 inhibitors (Ticagrelor) may be useful in Platelet-directed Tx & its effect on platelet S100A8/A9 , platelet-induced #endotheliopathy in #COVID19 📌https://t.co/7YoV1JTf8a @aaas 📌https://t.co/Ne8oFBvdwd @NICEComms @Vie
Platelets amplify endothelial pathology in COVID-19 https://t.co/bmdIMr6mww
Platelets amplify endotheliopathy in COVID-19 https://t.co/tDGKLZdp5G
RT @YouAreLobbyLud: Five year cardiovascular mortality post Covid is going to be an "interesting" metric. https://t.co/En6ax35Pms
RT @YouAreLobbyLud: Five year cardiovascular mortality post Covid is going to be an "interesting" metric. https://t.co/En6ax35Pms
Sars-CoV-2 vs CoV-OC43, labrahavaintoja eroista https://t.co/DGuumThMMd https://t.co/7eXIUHPGwv
RT @YouAreLobbyLud: Five year cardiovascular mortality post Covid is going to be an "interesting" metric. https://t.co/En6ax35Pms
RT @YouAreLobbyLud: Five year cardiovascular mortality post Covid is going to be an "interesting" metric. https://t.co/En6ax35Pms
#dkpol @SSTSundhed @Heunicke #dkmedier @regeringDK
RT @YouAreLobbyLud: Five year cardiovascular mortality post Covid is going to be an "interesting" metric. https://t.co/En6ax35Pms
RT @YouAreLobbyLud: Five year cardiovascular mortality post Covid is going to be an "interesting" metric. https://t.co/En6ax35Pms
@b_leeder @NattyBeaks @DrShaneRRR Not rare. Look overseas where Covid spread widely before now. It was mild for my daughter WHEN she had it. Like cancer. It doesn’t get you straight away. Good luck. https://t.co/JABA7ExAmo
RT @ygjumi: Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
RT @TonyFauci2: $ADMP Tempol reduces platelet induced damage to blood vessels in #COVID19 lungs - an issues which will re-emerge with the n…
$ADMP Tempol reduces platelet induced damage to blood vessels in #COVID19 lungs - an issues which will re-emerge with the next strain- and the next.
RT @PlateletDoc: Pleased to share 18 months of work demonstrating how #platelets play a major pathogenic role in #Covid_19 and amplify endo…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
$ADMP #COVID19 Advantage - part of the reason for NIH support:
Platelets - one unappreciated key to $ADMP Tempol upcoming success in #Covid Therapy.
The regulation of platelets in #COVID19 treatment -“findings demonstrate a previously unappreciated role for platelets and their activation-induced endotheliopathy in #COVID19” https://t.co/oHG2p1mUaG $ADMP role in restoration of normal platelet function c
RT @GhostPants8: @hjelle_brian COVID-19–exposed platelets change endothelial cells largely through a protein called P-selectin, which makes…
RT @GhostPants8: @hjelle_brian COVID-19–exposed platelets change endothelial cells largely through a protein called P-selectin, which makes…
@VirusesImmunity @KaminskiMed Endothelitis from hyperactivated platelets and oxLDL/oxHDL from COVID-19? https://t.co/nRp5dOylZj
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
@LL_BSN_RN @hjelle_brian Hypercoaguability during COVID-19 is well known, it continuing post-COVID is less known. https://t.co/nRp5dOylZj
RT @ygjumi: Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @calirunnerdoc: Bad news: More evidence COVID damages endothelium, causing inflammation and clots. This study looks at platelets- “cell…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
@renudhinakaran @ahandvanish Explanation of the persistence of microclots in #LongCovid: https://t.co/nRp5dOylZj
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
"Herein we demonstrate that platelets from COVID-19 patients are hyperactive and that platelet-released factors activate microvascular ECs, promoting an inflammatory hypercoagulable phenotype. Investigation of the platelet transcri…https://t.co/6T0BZmnAko
@KM_inLA This is why some patients need the combination of anticoagulants after COVID-19: https://t.co/nRp5dOylZj
Platelets amplify endotheliopathy in #COVID19 https://t.co/jp7ee4AGmd "MRP8/14 activates microvascular ECs and weakens EC cell-cell contacts, resulting in increased permeability of the endothelium" #LongCovid
Platelets amplify endotheliopathy in #COVID19 https://t.co/jp7ee4AGmd "targeting platelet P2Y12 represents a promising candidate to reduce proinflammatory platelet-endothelial interactions"
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @calirunnerdoc: Bad news: More evidence COVID damages endothelium, causing inflammation and clots. This study looks at platelets- “cell…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @ygjumi: Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
RT @ygjumi: Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
RT @ygjumi: Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
Very nice mechanistic study from @nyulangone on how activation of platelets modulate outcomes in #COVID19
RT @loscharlos: Platelets amplify endotheliopathy in COVID-19 “platelets from COVID-19 patients are hyperactive & platelet-released facto…