RT @aria606: @RTurniansky @hjelle_brian That makes sense. IIRC “innate immunity” keeps you from getting infected in the first place, while…
@RTurniansky @hjelle_brian That makes sense. IIRC “innate immunity” keeps you from getting infected in the first place, while “adaptive immunity” kicks in after. So SARS-COV-2 is able to get around our innate immunity. And it seems like new variants are ge
RT @UCSF_RDO: Evolution of enhanced innate immune evasion by SARS-CoV-2: mutations outside Spike are important to adaptation of SARS-CoV-2…
Evolution of enhanced innate immune evasion by SARS-CoV-2: mutations outside Spike are important to adaptation of SARS-CoV-2 to humans https://t.co/Mj2z0OUXBd
RT @abledoc: The ORF9b mutations demonstrated in this study using Alpha Variant are shared with Delta & Omicron. ORF9b interferes Tom70-MA…
The ORF9b mutations demonstrated in this study using Alpha Variant are shared with Delta & Omicron. ORF9b interferes Tom70-MAVS pathway of Interferon Responses to Viruses. Blocking it restores Interferon response. https://t.co/Ow78PmfLAg https://t.co/
Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/y0vZlSMGeF #science #genomics
RT @4141245879freun: Mutations outside Spike in adaptation of SC-2 to humans is underscored by the observation that similar mutations exist…
Mutations outside Spike are more important than we realize: https://t.co/SsZZ3IZXJE
Trending on PubMed: Evolution of enhanced innate immune evasion by SARS-CoV-2. https://t.co/HKZeYu0PVk
"Omicron is just like a cold. It will make your immune system stronger and more resilient." What about "ehh, not really". https://t.co/SXvjiuMNlP
Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/HbDF9KyrQP #covid19
Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/tSXHtkD7c8 #covid19
RT @jojobickley: In this report, the Omicron variant carries a mutation that may weaken innate immunity, a molecular alarm that rapidly act…
Evolution of enhanced innate immune evasion by SARS-CoV-2 | Nature https://t.co/njYO5M7vvQ
コロナウイルスの変異株、スパイクタンパク質の変異ばかりに目が行っていましたが、ウイルスのタンパク質(Orf9bなど)によって感染した人の免疫から逃れるということ。このたんぱく質の変異で、より感染性が増すとか。 https://t.co/hSKDJ41eCA
RT @DoctorBou: I am super excited about our paper out in @Nature today. It may be expected that viruses evolve to enhance innate immune sup…
Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/rcNGjiHcci #science #genomics
Evolution of enhanced innate immune evasion by SARS-CoV-2 | Nature https://t.co/3MIURhtNE7
Mutations outside Spike in adaptation of SC-2 to humans is underscored by the observation that similar mutations exist in Delta https://t.co/OgfiEeNNA3 ...interact with cellular organelles leading to suppression of the antiviral response in infected cells.
Evolution of enhanced innate immune evasion by SARS-CoV-2 | Nature #longCOVID https://t.co/x6yw9zzr3D
Evolution of enhanced innate immune evasion by SARS-CoV-2 | Nature https://t.co/UCHlGfGewp
scientists "have to start looking at mutations outside the spike" which has so far been the main focus of vaccines and antibody drugs… #IDtwitter #COVIDnews https://t.co/E1NTmoC21e
RT @lucygthorne: Excited to finally share our SARS-CoV-2 paper in @Nature !! 🙌 Have learnt so much being part of this amazing team @akreusc…
Ако ве интересира на долго и широко и ако не верувате на медиуми: https://t.co/AdDAupMa5m https://t.co/lefPeWQw7k Сепак повеќе верувам на научници
Evolution of enhanced innate immune evasion by SARS-CoV-2 | Nature https://t.co/1qUXuTKiSN
コロナによる自然免疫回避の強化進化https://t.co/kbetBtsN8H 図5 Alphaは既知の自然免疫拮抗物質Orf9b,Orf6,N増加 →RNA感知阻害 in vivoでAlphaによる自然免疫拮抗の強化→宿主の初期自然反応を低減/遅延→複製促進→伝達優位性に寄与? でなければ気道細胞を感染から守り、ウイルス播種制限する
Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/tOHg0raXOf
Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/jAPLAmg2YG #science
With higher levels of Orf9B disabling TOM70, the immune system does not respond as well and the virus can better evade detection, the researchers said. https://t.co/i24rfIfNcm
Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/trHrzLQ4kc #covid19
N, Orf9b, Orf6 “We found that Alpha has dramatically increased subgenomic RNA and protein levels of N, Orf9b & Orf6, all known innate immune antagonists.” #SARSCoV2 Thanks to https://t.co/yXaiHmlj2H ref.
N, Orf9b “The importance of mutations outside Spike in adaptation of #SARSCoV2 to humans is underscored by the observation that similar mutations exist in the Delta & Omicron N/Orf9b regulatory regions.” Thanks to https://t.co/yXaiHmlj2H ref.
① ORF9b “Expression of Orf9b alone suppressed the innate immune response through interaction with TOM70, a mitochondrial protein required for RNA sensing adaptor MAVS activation.” #SARSCoV2 https://t.co/yXaiHmlj2H ③-1. ORF8 https://t.co/hrNPL8Btfg ref
RT @abledoc: Alpha evolved superior innate Immune evasion vis a vis early COVID19 strains Cant wait to see @KroganLab results on Delta and…
Alpha evolved superior innate Immune evasion vis a vis early COVID19 strains Cant wait to see @KroganLab results on Delta and Omicron to see the trend in innate immune evasion. Enhanced evasion may reduce acute disease severity while worsening long haul h
Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/ulO5KjH0P7 #covid19
Evolution of enhanced innate immune evasion by SARS-CoV-2 | Nature https://t.co/TQ5vv26gjO
RT @pedrobeltrao: Out today - Evolution of enhanced innate immune evasion by SARS-CoV-2. By Krogan lab and many others with a small contrib…
Evolution of enhanced innate immune evasion by SARS-CoV-2 | Nature 研究者たちは、この変異株がいわゆる自然免疫を弱める可能性があることを報告した。自然免疫とは、鼻からの侵入の最初の兆候で免疫システムを迅速に作動させる分子アラームのことである。 #オミクロン https://t.co/RXqxpuNSn5
RT @jojobickley: In this report, the Omicron variant carries a mutation that may weaken innate immunity, a molecular alarm that rapidly act…
Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/sGL7Ubcq5Y #science
In this report, the Omicron variant carries a mutation that may weaken innate immunity, a molecular alarm that rapidly activates our immune system at the first sign of an invasion in the nose. https://t.co/gquxRCfXAx
Evolution of enhanced innate immune evasion by SARS-CoV-2 | Nature https://t.co/VtHVp06rfo
RT @KroganLab: How do SARS-CoV-2 variants evolve to become more transmissible? One contributor, which we report today in @Nature, is increa…
RT @Anisopterid: Unfortunately the answer is: an extremely permissive one. Beyond Spike, there are other proteins in SCV2 that interfere w…
RT @lucygthorne: Excited to finally share our SARS-CoV-2 paper in @Nature !! 🙌 Have learnt so much being part of this amazing team @akreusc…
@EddieC_Tweets No, it doesn't. And well, it does. Business as usual - at least, as much as "possible". No real actions. Protect the 2% vulnerable and produce a strain that makes everyone vulnerable. On the long run, that's gonna solve the problem. All easy
RT @lucygthorne: Excited to finally share our SARS-CoV-2 paper in @Nature !! 🙌 Have learnt so much being part of this amazing team @akreusc…
RT @lucygthorne: Excited to finally share our SARS-CoV-2 paper in @Nature !! 🙌 Have learnt so much being part of this amazing team @akreusc…
RT @akreuschl: Brilliant thread by @lucygthorne ⬇️
RT @sergeilkp: Very cool study! 1. Spike is NOT everything 2. Evolutionary adaptation can occur in ways other than new protein function/i…
RT @drjkahn: Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/6LkmuSJ7Hm
Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/6LkmuSJ7Hm
RT @KroganLab: How do SARS-CoV-2 variants evolve to become more transmissible? One contributor, which we report today in @Nature, is increa…
RT @lucygthorne: Excited to finally share our SARS-CoV-2 paper in @Nature !! 🙌 Have learnt so much being part of this amazing team @akreusc…
RT @lucygthorne: Excited to finally share our SARS-CoV-2 paper in @Nature !! 🙌 Have learnt so much being part of this amazing team @akreusc…
RT @lucygthorne: Excited to finally share our SARS-CoV-2 paper in @Nature !! 🙌 Have learnt so much being part of this amazing team @akreusc…
RT @maini_lab: Important work reminding us immune evasion is not all about antibodies or even T cells this time…congratulations to our frie…
Important work reminding us immune evasion is not all about antibodies or even T cells this time…congratulations to our friends @lucygthorne @akreuschl and @towerslab @Jolly_lab
Evolucija izboljšanja SARS-CoV2 pobega pred prirojeno imunostjo... https://t.co/DouYu9mvXn
今回のパンデミックで感染症の研究が一気に進んでいるけど、まだまだ免疫は奥が深いんですね。
Evolution of enhanced innate immune evasion by SARS-CoV-2 👉https://t.co/tOHg0raXOf
RT @lucygthorne: Excited to finally share our SARS-CoV-2 paper in @Nature !! 🙌 Have learnt so much being part of this amazing team @akreusc…
Evolution of enhanced innate immune evasion by SARS-CoV-2 https://t.co/X47bN2N7VA
@Ebolasahn @DIVIZIO1 Omicron descend de Alpha (né avril 2020 Autriche alors que 2 soldats ukrainiens étaient décédés dans les essais Moderna quelques semaines auparavant) & de Delta: vague de la vaccination traitée à l'agent mutagène Remdesivir de Gile
RT @Pr_Logos: 361/ Les mutations adaptatives de SARS-CoV-2 ne se font pas uniquement sur la protéine Spike mais également sur des protéines…
RT @KroganLab: How do SARS-CoV-2 variants evolve to become more transmissible? One contributor, which we report today in @Nature, is increa…
RT @Pr_Logos: 361/ Les mutations adaptatives de SARS-CoV-2 ne se font pas uniquement sur la protéine Spike mais également sur des protéines…
RT @Pr_Logos: 361/ Les mutations adaptatives de SARS-CoV-2 ne se font pas uniquement sur la protéine Spike mais également sur des protéines…
RT @Pr_Logos: 361/ Les mutations adaptatives de SARS-CoV-2 ne se font pas uniquement sur la protéine Spike mais également sur des protéines…
RT @Pr_Logos: 361/ Les mutations adaptatives de SARS-CoV-2 ne se font pas uniquement sur la protéine Spike mais également sur des protéines…
361/ Les mutations adaptatives de SARS-CoV-2 ne se font pas uniquement sur la protéine Spike mais également sur des protéines qui désactivent la réponse innée, c'est-à-dire la défense de première ligne présente dans les cellules. https://t.co/2ECubRHEqx
RT @guty2370: "Un éxito rotundo para el coronavirus": descubren que la variante alfa ha aprendido a bloquear el sistema inmunitario. https:…
RT @guty2370: "Un éxito rotundo para el coronavirus": descubren que la variante alfa ha aprendido a bloquear el sistema inmunitario. https:…
"Un éxito rotundo para el coronavirus": descubren que la variante alfa ha aprendido a bloquear el sistema inmunitario. https://t.co/MVkZIs2rY9
Outside #Spike proteins, mutations & regulation of #SARS_CoV_2 proteins that evade innate #Immunity (e.g., N, Orf9b, Orf6) may help understand VOC like Alpha, Delta, #omicronvariant. Structure of Orf9b-human TOM70 complex (PDB 7kdt) provides insights.
Unfortunately the answer is: an extremely permissive one. Beyond Spike, there are other proteins in SCV2 that interfere with the innate immune response -- our first line of systemic organ defense -- which are also undergoing adaptive evolution: https://t
RT @lucygthorne: Excited to finally share our SARS-CoV-2 paper in @Nature !! 🙌 Have learnt so much being part of this amazing team @akreusc…
Worth reading the research as well. Study link: https://t.co/TV8eY1rIvx
Evolution of enhanced innate immune evasion by SARS-CoV-2 "The importance of mutations outside Spike in adaptation of SARS-CoV-2 to humans is underscored by the observation that similar mutations exist in the Delta and Omicron N/Orf9b regulatory regions"
RT @docdrugztore: si diffondesse per via aerea, proprio come il #SARSCoV2… D’altronde, studi recenti mostrano che quest’ultimo ha sul nostr…
RT @tg128: Στο paper αυτό δείχνεται πως ο ιός καταφέρνει και ξεφεύγει από την έμφυτη (όχι την προσαρμοσμένη) ανοσία. Αυτό δείχνει για άλλη…
@EricTopol @dr_kkjetelina @SubstackInc I think you would have to prove that this universal super vaccine isn't putting pressure on the core of the virus to start mutating just as rapidly as the spike has. And also make sure the sequences are not shutting d
RT @tg128: Στο paper αυτό δείχνεται πως ο ιός καταφέρνει και ξεφεύγει από την έμφυτη (όχι την προσαρμοσμένη) ανοσία. Αυτό δείχνει για άλλη…
RT @tg128: Στο paper αυτό δείχνεται πως ο ιός καταφέρνει και ξεφεύγει από την έμφυτη (όχι την προσαρμοσμένη) ανοσία. Αυτό δείχνει για άλλη…
RT @neznezxmail: 【SARS-CoV-2による増強された自然免疫逃避の進化】 ★Alphaは,自然免疫拮抗物質(アンタゴニスト)として知られる,N,Orf9b,Orf6のサブゲノムRNAおよびタンパク質レベルを劇的に増加させる ★DeltaおよびOmicron…
RT @lucygthorne: Excited to finally share our SARS-CoV-2 paper in @Nature !! 🙌 Have learnt so much being part of this amazing team @akreusc…
RT @lucygthorne: Excited to finally share our SARS-CoV-2 paper in @Nature !! 🙌 Have learnt so much being part of this amazing team @akreusc…
$tsoi
RT @stefaniaconti: "Il nostro lavoro mostra come SARS-CoV2 si sta evolvendo per superare meglio il nostro sistema immunitario innato sin da…